Posts Tagged ‘Progressive Disease’

New Drug Shows Promise Growing Brain Cells

Friday, August 20th, 2010

Alzheimer’s patients, brain injury patients, and dementia sufferers may benefit from a newly discovered pill that grows brain cells. The drug, currently labeled P7C3 while it undergoes continued study, appears to provide a safe and effective option that helps support developing brain cells to become viable. Testing done on rats demonstrated that the older rats who had been dosed with P7C3 were capable of learning their way

through a maze when other rats, who had not received the drug, could not. The researchers hope the drug can be used to increase the effectiveness of Alzheimer’s drugs like Dimebon, which recently failed in clinical trials.

“For the sake of patients suffering from Alzheimer’s disease, it is hoped that the apparently marginal clinical utility of Dimebon might be enhanced by improvements in both its potency and ceiling of proneurogenic, neuroprotective efficacy,” the researchers wrote. “If so, our work offers concrete assays for the development of improved versions of these neuroprotective drugs.”

More than 25 million people currently suffer from Alzheimer’s disease, which is a progressive disease that destroys the brain until autonomic functions cease and the sufferer dies. P7C3 represents a hopeful breakthrough in research that could lend itself to other areas of brain trauma treatment, including helping people with ALS (also known as Lou Gehrig’s disease).

Dr. Thomas Insel, director of the National Institute on Mental Health, said, “This striking demonstration of a treatment that stems age-related cognitive decline in living animals points the way to potential development of the first cures that will address the core illness process in Alzheimer’s disease.” The National Institute on Mental Health helped fund the study.

The rats that were treated with the drug had three times as many developing brain cells. Researchers have since used P7C3 to create a derivative drug called A20 that shows even more promise. When the derivative was combined with Dimebon and Sereno, two test-phase Alzheimer treatments, it caused new brain cell growth stimulation.

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Cholinesterase Inhibitors – Their Use and Withdrawl of Treatment

Sunday, April 19th, 2009

The cholinteresterase inhibitors thus far available  are currently only approved by the F.D.A. (The US Food and Drug Administration)  , are approved by the FDA as only being effective for Alzherimer patients who have thus far mild to moderate disease.  However these drugs and medications – that is the cholinesterase classification medication grouping, may well show promise for those who are in the earliest as well as later stages of the disease , as well.  In addition they could well be of benefit and benefits to those with mil cognitive impairment as well.

One large study evaluated the use of Aricept (dozepezil) in the treatment of mild cognitive  impairment and found that it significantly reduced conversion to active Alzheimer’s progressive disease.

Current Treatment for Alzheimer’s Disease – Prescription cholinesterase inhibitors include Exelon and Aricept. These drugs have varying side effects and can have contraindications with other medication, so it can be difficult for doctors to find the right pharmaceutical match and …

Methods and compositions using cholinesterase inhibitors – The invention provides methods for treating and/or preventing Alzheimer’s disease, psychiatric illnesses, encephalitis, meningitis, fetal alcohol syndrome, Karsakoff’s syndrome, anoxic brain injury, cardiopulmonary resuscitation …

alzheimer disease – These drugs are called cholinesterase inhibitors because they inhibit the enzymes that break down acetylcholine (acetylcholinesterase and butyrylcholinesterase). Some drugs target only acetylcholinesterase, whereas some target both …

Galantamine: Welsh daffodils containing galantamine may help fight … – Galantamine is a competitive and reversible cholinesterase inhibitor. It is believed it works by enhancing cholinergic function by increasing the concentration of acetylcholine in the brain. The atomics resolution 3D structure of the …

Cholinesterase Inhibitors Reduce Aggression, Wandering And … – Cholinesterase Inhibitors Reduce Aggression, Wandering And Paranoia In Alzheimer’s Disease.

While cholinesterase inhibitors are now believed to he most helpful in persons with severe Alzheimer’s disease ,sometimes patients can be maintained on these classes and classifications of drugs indefinitely due to the fact and observation that in clinical practice , that often patients who stop taking these drugs or types of medications deteriorate rapidly when the drugs are arbitrarily stopped or withdrawn.  Indeed there is new and upcoming evidence from studies that suggest that stopping cholinesterase inhibitors will result in decline in functioning to a level that the patient would have been at it they – he or she – had not been taking the drug in the first place.

In addition drugs in this class appear to have an added benefit in improving behaviour as well as overall cognitive abilities.

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http://www.dimebonalzheimers.com

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