Archive for January, 2009

Aricept: Common side Effects

Thursday, January 29th, 2009

Common Side Effects of Aricept ( generically known as doneperzil) , include possible nausea, vomiting , diarrhea, bruising, fainting , insomnia or “not sleeping well”, loss of appetite, feeling tired and finally possibility of muscle cramps and cramping.

Most of these side effects could be said to mild and tend or tended to subsidize as the body adjusts to the medication over a number of days or extended time period .? Aricept may be more likely than Exelon or Razadyne to cause mild sleep problems such as vivid dreams as well as possible nocturnal illusions.? Urinary problems? are often occasionally seen with the use of Aricept.

Dimebon Alzheimer?s Disease

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Aricept (Donepezil)

Thursday, January 29th, 2009

Aricept can be said to have been studied longer , and in more patients two similar medications or so that are in present medical and pharmaceutical use.? Aricept is the easiest to use of the pharmaceutical choices and is often noted as being the best tolerated by patients over the alternative treatments.?? Aricept clears more slowly than the other drugs from the body.? Shorter half lives or longer half lives for drugs have both good and bad points in consideration of the treatment choice for the specific patient and treatment plan in view.

Compliance ( the percent of the time that patients take the medication as prescribed or recommended? properly as described is estimated generally at 50 %).??? The “studies”? show and demonstrate that little can be done to improve compliance levels of drugs, other than making the treatment regime easier? and less complex , or to tie in the taking of the pills , tablets , liquid or whatever the form the medication is in? with a daily habit of the patient – say a meal or shaving time in the morning.?? The other way to enhance compliance is to make the regimen simpler – say for example by making the medicine choice 2 times a day instead of 4 times a day.

With medications with a longer half life if the patient does mean taking a dose, there is still some drug or drug levels left in the body.Hence the drug will stay be in the body and serum to some level .? This is an advantage for the drug Aricept.? On the other side of the fence if side effects are a problem these side effects will last longer and take a longer time to clear.? Often though one way of dealing with this is to start with lower dosages initially in the first time periods.? On top of that patients can often get “used to a drug”? taken this way , starting off with lower dosages rather than blasting the patient from the beginning.? Started at lower levels and dosages initially patients can often be treated with medications and medication dosages that side effects would limit otherwise. On top of that most Alzheimer patients are being treated with a range of multitude of different drugs and medications already whose side effect interactions are often unstudied or unknown or both.

Only one dose of the drug Aricept is needed as a standard dose per day.? Its a fairly simple regimen.? Aricept as a result is widely used for Alzheimer’s patients.? Its benefits for Alzheimer’s patients can last up to a year.

Dimebon Alzheimer?s Disease

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Be Forewarned and Informed Concerning Alzheimer's disease and Its Treatments

Monday, January 26th, 2009

If you are like most people, you may well benefit with relevant and most importantly accurate information that will provide you with both accurate and relevant information concerning the facts , fiction and myths of Alzheimer’s disease and its treatment as well as diagnosis.

You owe it to both yourself and your family to be properly informed.

For example :  information on the diagnosis and treatment of early and middle stage Alzheimer’s disease including numerous new developments that either your doctor may not be aware of , or may not or hit either the publication stage in medical reports or journals , or even the popular press – famous for “inside information” that may be accurate or non accurate information meant to solely increase ad circulations of those specific publications

Coverage of the earliest warning signs of Alzheimer’s , such as mild cognitive impairment or impairments and cognitive impairment no dementia ( CIND0, conditions that may be precursors to Alzheimer’s diseae or related disorders

-                  Detailed descriptions of why and  when a person needs a medical evaluation, who to find the “best doctors” and when to get a second opinion – including eye-opening examples of missed opportunities to get help at early to moderate stages of the disease

state of the art advice on the medical treatment fo early to middle stage Alzheimer’s . including the latest studies of treatments approved by th FDa as well as so called off label ( non approved but may of use or have anecdotal reports associated with it of beneficial effects of treatment) where the drugs , drug or agents may appear to have a beneficial effect of effects but are not yet approved or approval by the regulatory authorities is in the process of being evaluated but yet not completed yet.

Lastly expert advice on psychotropic drugs for treating depression , anxiety, insomnia and behavioral problems in people in the middle and early stages of Alzheimer’s including the latest information on both prescription and non perscription treatments as well as their adverse effects.

 

Alzheimer’s Reading Room: Is Etanercept the Cure for Alzheimer’s – Alzheimer’s has now surpassed diabetes as the sixth leading cause of death. If no cure or preventative medication is found, ten million baby boomer’s can expect to suffer from Alzheimer’s disease. With a potential market of that size …

Alzheimer’s Reading Room: Can Apple Juice Delay the Onset of … – In theory, grape, apple and orange juices are very potent in antioxidants and could be the most effective at preventing Alzheimer’s disease, according to Dr. Larson. In the study, those who did not drink fruit juice, but ate several …

Alzheimers? Disease sufferers should get fully funded care, says … – TRAPPED in a world of confusion Alzheimers? sufferer Hector Atkinson cannot talk, feed, dress or even recognise his loved ones? faces.

Dimebon Alzheimer?s Disease

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Misconceptions and Misunderstandings Concerning Alzheimer's Disease

Monday, January 26th, 2009

It can be said that there are no shortage of misconceptions that are commonly held in relation to Alzheimer’s Disease and dementia in general.

Among these are :

-  that people get Alzheimer’s Disease in their forties or fifties

- that dementia is the same as senility or aging

- that if your mother developed Alzheimer’s Disease in her eighties, you have a close to 95 % percent chance of getting it as well

-  Alzheimer’s brain changes may start years or decades before memory problems begin or become fully apparent

- specialists can tell up to 90 %  accuracy whether or not someone has Alzheimer’s

- a depressed mood or vitamin deficiency can impair one’s memory

- there is no approved medication or medications for treating Alzheimer’s symptoms.  The only option , as the misinformed or those with misconceptions are for “experimental drugs”

- high blood pressure or obesity may increase one risk of dementia.  “You eat too much” may be the refrain from dietitian types who see all health evils as a result of overeating

-  being socially involved and keeping one’s mind active may postpone Alzheimer’s

- that all clinical research studies involve taking risky experimental drugs.

 

Education cannot protect against Alzheimer’s, study finds … – Advanced levels of education do not protect against Alzheimer’s disease, according to a new study that contradicts a number of earlier reports on the topic.

Shawn’s Health Blog: More research into genetic link to … – Scientists have known for more than a decade that individuals with a certain gene are at higher risk for developing Alzheimers disease. Now a new study helps explain why this is so.The research, led by scientists at the Oklahoma Medical …

Insulin Shields Brain from Alzheimer?s | TopNews United States – Sensitivity to insulin can decline with aging, which presents a novel risk factor for Alzheimer’s disease. Our results demonstrate that bolstering insulin signaling can protect neurons from harm.” …

Midlife Onset of Diabetes Doubles Risk of Alzheimer?s Disease … – See Larger Image Below (Best Syndication News) Research indicates that there is a link between Alzheimer?s disease and diabetes, especially if the onset of diabetes occurs in middle age. Twin studies performed in Sweden indicate that …

Dimebon Alzheimer?s Disease

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Early Clinical Pharmacologic Work with Dimebolin as a Adjunct Thereputic Agent

Thursday, January 15th, 2009

Russian research done in the year 2000 has shown beneficial effects of the chemical dimebolin hydrochloride on patients being treated for Alzheimer’s disease.   Indeed using this agent  on what are considered  models of Alzheimer’s disease in animal subjects returned similar results.  Hence the initial models were in place and these were corroborated with early initial testing in human subjects.

The mechanism of the action of the drug seems to be that the agent in its chemical form not only acts as an anti-histamine ( anti histamine)  but also inhibits brain cell death.  Hence dimebolone as a  therepeutic agent shows promise not only in the treatment and treatments of Alzheimer’s Disease  but also in Huntington’s Disease as well as  a host of other neurodegenerative diseases.

The future looks bright for the agent Dimebolin in various thereputic avenues.  More work and progress will need to be done.

Early Clinical Pharmacologic Work with Dimebolin as a Adjunct … – Russian research done in the year 2000 has shown beneficial effects of the chemical dimebolin hydrochloride on patients being treated for Alzheimer?s disease. Indeed using this agent on what are considered models of Alzheimer?s disease …

Dimebon Dimebolin Information Availability – Dimebom is a new pharmaceutical treatment alternative for patients suffering from Alzheimer?s Disease. Dimebon is an older medication that has recently been discovered to be most helpful in treating patients with Alzheimer?s Disease …

antihistamine : Diggs – 2009-Jan-26 : Dimebon Dimebolin … – Dimebon Dimebolin Alzheimer’s Information Availability – Natural Sources of Antihistamine – How Do Antihistamines Work for Allergies?

Call for help. Searching for a drug: Dimebolin – Hello all, My good friend’s father was recently diagnosed with Alzheimer’s disease. He tried several medications with much success. After doing some research he found out that there is a drug called Dimebolin (brand name Dimebon), …

Prous Science – Dimebolin hydrochloride (Dimebon?) is an orally-available, small-molecule agent that is in clinical testing for the treatment of Alzheimer’s and Huntington’s diseases-two progressive, devastating conditions with limited treatment …

Current Research into Dimebon – Dimebon ( chemically or the generic term Dimebolin) has attracted a fair amount of attention both in the medical , lay and popular press. The options available for the treatment of Alzheimer?s patients are limited , the disease is so …

 

 

 

Alzheimer’s Disease Dimebon Over the Counter Russian Anti-histamine

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Current Research into Dimebon

Wednesday, January 14th, 2009

Dimebon ( chemically or the generic term Dimebolin) has attracted a fair amount of attention both in the medical , lay and popular press. The options available for the treatment of Alzheimer’s patients are limited , the disease is so devastating , so that any new therapies or newer therapies that invoke hope are well received.

The problem basically with any new drug , medication or formulations introduced to the marketplace boil down basically to one of numbers and drug interactions. Any medication that is released to the marketplace is basically and essentially only tested on a relatively very small group of patients / victims.

Its not that the testing process is slipshod. It is not and is well is very expensive. Its just that the numbers are relatively small in limited situations. The first thing that is always tested for is safety. If the drug is inherently unsafe then the whole process should be stopped. This potentially does not come into play if the drug will save some people in a situation where nothing else will. Everything in life of course , always comes to risks vs benefits.

The basic problem with drug testing and introduction is simply a matter of numbers , percentages , and interactions with medications or other agents not thought of , or not tested.

It all boils down to statistics and numbers. 1/100 of a percent involving a trial with 100 or even 1000 patients may not uncover damming side effects whereas if that same product is released into the marketplace , with millions of users and patients , and whammo that terrible side effect comes to light now . Not only that when multiplied out , the amount of patients affected adversely is not small , and is indeed large and troubling. The question will be why these interactions and side effects not found , noticed or detected before ?

Which brings up to the beauty of this specific chemical / medication to be used in the treatment of Alzheimer’s Disease.

Dimebon or Dimbolin is an older antihistamine drug which was used in Russia / U.S.S.R. as a widely available medication that was used in great numbers and prevalence for a good period of time. The drug was widely used as it was available easily and widespread without even a prescription. There do not appear to have enough problems with the medication that many problems seem to have be reported with its use.

 

dimebon is cure of alzheimer?s disease? – recently dimebolin has sparked renewed interest after being shown to have positive effects on people suffering from alzheimer?s disease. animal studies showing the potential beneficial effects on alzheimer?s disease models were …

comfort for the afflicted – for example, the antihistamine dimebolin hydrochloride preserved cognition in an 18-month investigation. and the antimalarial methylthioninium chloride interfered with the accumulation of tau tangles in the brain in an 84-week study. …

Pfizer pays $725 Million for experimental drug (Life, Liberty, and … – Pfizer said that it was acquiring the rights to a new experimental substance aimed to help Alzheimer’s disease. The substance (Pictured Above) is Dimebolin, a antihistamine that works on the AMPA/NMDA receptors. …

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Dimebon Dimebolin Information Availability

Wednesday, January 14th, 2009

Dimebom is a new pharmaceutical treatment alternative for patients suffering from Alzheimer’s Disease

Dimebon is an older medication that has recently been discovered to be most helpful in treating patients with Alzheimer’s Disease

Dimebon ( the actual drug is known chemically as Dimebolin) is an older Russian antihistamine drug.  It was popularly used in Russia as an antihistamine for hayfever , allergies and the like.  In fact the drug was sold as an easy to obtain antihistamine -  sold over the counter without a prescription.

Dimebon is currently in clinical trials in the United States by a company named  Medivation . The website for Medivation company can be found at http://www.medivation.com/

Dimebon and the clinical trial information of Medivation can be found at this link on the internet

http://www.medivation.com/pipeline_dimebontrials.html

At this point in time Dimebon is not available in any manner outside of the study material afforded by the Medivation company and the Medivation clinical trials themselves.

Dimebon Alzheimer’s Disease

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